Amastatin hydrochloride 

Amastatin hydrochloride is a slow, tight binding, competitive aminopeptidase (AP) inhibitor with K_i values of 0.26 nM, 30 nM, 52 nM for Aeromonas aminopeptidase, cytosolic leucine aminopeptidase, microsomal aminopeptidase^[1].

Amastatin hydrochloride (1-10000 ng/ml) exhibitcd inhibitory profiles of E. cuniczcli replication in vitro in a dose dependent manner^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

511.01

C₂₁H₃₉ClN₄O₈

100938-10-1

O=C(O)C[C@@H](C(O)=O)NC([C@H](C(C)C)NC([C@H](C(C)C)NC([C@@H](O)[C@H](N)CC(C)C)=O)=O)=O.[H]Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. S H Wilkes, et al. The Slow, Tight Binding of Bestatin and Amastatin to Aminopeptidases. J Biol Chem. 1985 Oct 25;260(24):13154-62.  [Content Brief]

  [2]. J J Millership, et al. In Vitro and in Vivo Evaluation of Aminopeptidase Inhibitors as Antimicrosporidial Therapies. J Eukaryot Microbiol. 2001;Suppl:95S-98S.  [Content Brief]