Ambelline

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Ambelline is an alkaloid that can be isolated from the Amaryllidaceae family. Ambelline shows antimalarial activity against Dd2 P. falciparum strain, with an IC₅₀ of 7.3 ± 0.3 μM.

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Ambelline Chemical Structure

CAS No. : 3660-62-6

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Description

Ambelline is an alkaloid that can be isolated from the Amaryllidaceae family. Ambelline shows antimalarial activity against Dd2 P. falciparum strain, with an IC₅₀ of 7.3 ± 0.3 μM^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 10 μM Compound: 11	Cytotoxicity against human A549 cells after 72 hrs by MTT colorimetric assay Cytotoxicity against human A549 cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]
B16-F10	IC₅₀	> 10 μM Compound: 11	Cytotoxicity against mouse B16F10 cells after 72 hrs by MTT colorimetric assay Cytotoxicity against mouse B16F10 cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]
Hs 683	IC₅₀	> 10 μM Compound: 11	Cytotoxicity against human Hs683 cells after 72 hrs by MTT colorimetric assay Cytotoxicity against human Hs683 cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]
SK-MEL	IC₅₀	> 10 μM Compound: 11	Cytotoxicity against human SK-MEL cells after 72 hrs by MTT colorimetric assay Cytotoxicity against human SK-MEL cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]
U-373MG ATCC	IC₅₀	> 10 μM Compound: 11	Cytotoxicity against human U373 cells after 72 hrs by MTT colorimetric assay Cytotoxicity against human U373 cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]

Molecular Weight

331.36

Formula

C₁₈H₂₁NO₅

CAS No.

3660-62-6

SMILES

O[C@H](C1)[C@]23C4=CC(OCO5)=C5C(OC)=C4C[N@]1[C@]2([H])C[C@@H](OC)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Breiterová KH, et al. Derivatives of Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Hepatic Stage of Plasmodium berghei Infection In Vitro. Pharmaceutics. 2023 Mar 21;15(3):1007. [Content Brief]

[2]. Ritomská A, et al. Design of semisynthetic derivatives of the Amaryllidaceae alkaloid ambelline and exploration of their in vitro cytotoxic activities. Saudi Pharm J. 2023 Aug;31(8):101684. [Content Brief]

Ambelline Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ambelline3660-62-6ParasiteInhibitorinhibitorinhibit

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