Ametantrone (Synonyms: NSC 196473; NSC 290813)

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Ametantrone (NSC 196473) is an antitumor agent that intercalates into DNA and induces topoisomerase II (TOP2)-mediated DNA break.

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Ametantrone Chemical Structure

CAS No. : 64862-96-0

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Description

Ametantrone (NSC 196473) is an antitumor agent that intercalates into DNA and induces topoisomerase II (TOP2)-mediated DNA break^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	0.17 μg/mL Compound: 2	Effective concentration required to inhibit by 50% the growth of HeLa S3 cells Effective concentration required to inhibit by 50% the growth of HeLa S3 cells	[PMID: 3172129]
HeLa	IC₅₀	0.9 μM Compound: Ametantrone	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 28342691]
HeLa	IC₅₀	0.9 μM Compound: Ametantrone	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 27521587]
HeLa	ED₅₀	3.1 mM Compound: AM	Effective concentration against cell growth of HeLa cell line by 50% Effective concentration against cell growth of HeLa cell line by 50%	[PMID: 8759632]
HL-60	ED₅₀	0.88 mM Compound: AM	Effective concentration against cell growth of HL60 cell line by 50% Effective concentration against cell growth of HL60 cell line by 50%	[PMID: 8759632]
HL-60	GI₅₀	29 nM Compound: AT, ametantrone	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 17962028]
HL60/MX2	GI₅₀	430 nM Compound: AT, ametantrone	Cytotoxicity against DNA topoisomerase-2 deficient human HL60/MX2 cells by MTT assay Cytotoxicity against DNA topoisomerase-2 deficient human HL60/MX2 cells by MTT assay	[PMID: 17962028]
L1210	ED₅₀	0.1 mM Compound: AM	Effective concentration against cell growth of L1210 cell line by 50% Effective concentration against cell growth of L1210 cell line by 50%	[PMID: 8759632]
L1210	EC₅₀	1.77 μg/mL Compound: 2	Effective concentration required to inhibit by 50% the growth of L1210 cells Effective concentration required to inhibit by 50% the growth of L1210 cells	[PMID: 3172129]
L1210	EC₅₀	275 nM Compound: AME	Concentration of compound required to inhibit the cellular protein biosynthesis by 50% Concentration of compound required to inhibit the cellular protein biosynthesis by 50%	[PMID: 8421288]
MCF7	IC₅₀	0.51 μM Compound: Ametantrone	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 28342691]
MCF7	IC₅₀	0.51 μM Compound: Ametantrone	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 27521587]
MCF7	GI₅₀	4.97 μM Compound: AT, ametantrone	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 17962028]
NCI-H460	GI₅₀	2.55 μM Compound: AT, ametantrone	Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 17962028]
PC-3	GI₅₀	8.52 μM Compound: AT, ametantrone	Cytotoxicity against human PC3 cells after 48 hrs by SRB assay Cytotoxicity against human PC3 cells after 48 hrs by SRB assay	[PMID: 17962028]
SF-268	GI₅₀	2.45 μM Compound: AT, ametantrone	Cytotoxicity against human SF268 cells after 48 hrs by SRB assay Cytotoxicity against human SF268 cells after 48 hrs by SRB assay	[PMID: 17962028]

Molecular Weight

412.48

Formula

C₂₂H₂₈N₄O₄

CAS No.

64862-96-0

SMILES

O=C1C2=C(C=CC=C2)C(C3=C(NCCNCCO)C=CC(NCCNCCO)=C13)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lee CH, et al. Anthracenedione-methionine conjugates are novel topoisomerase II-targeting anticancer agents with favorable drug resistance profiles. Biochem Pharmacol. 2012;83(9):1208-1216. [Content Brief]

Ametantrone Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ametantrone64862-96-0NSC 196473 NSC 290813NSC196473NSC-196473NSC290813NSC 290813NSC-290813DNA/RNA SynthesisDNA breakantitumor agentanthracenedioneDNA bindingInhibitorinhibitorinhibit

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