2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. AMG-628

AMG-628 is an orally active inhibitor for TRPV1, that inhibits Capsaicin (HY-10448) or acid (pH 5)-induced Ca2+ influx into TRPV1- expressing CHO cell with IC50 of 4.9 and 3.1 nM. AMG-628 exhibits analgesic activity in Capsaicin (HY-10448)-induced rat model, and exhibits a half-life of 2.4 h in rats.

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AMG-628 Chemical Structure

AMG-628 Chemical Structure

CAS No. : 862269-93-0

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AMG-628 Related Antibodies

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Description

AMG-628 is an orally active inhibitor for TRPV1, that inhibits Capsaicin (HY-10448) or acid (pH 5)-induced Ca2+ influx into TRPV1- expressing CHO cell with IC50 of 4.9 and 3.1 nM. AMG-628 exhibits analgesic activity in Capsaicin (HY-10448)-induced rat model, and exhibits a half-life of 2.4 h in rats[1].

Molecular Weight

492.57

Formula

C25H25FN6O2S
CAS No.
SMILES

CC(NC1=NC2=C(OC3=NC=NC(N4CCN([C@@H](C5=CC=C(F)C=C5)C)CC4)=C3)C=CC=C2S1)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AMG-628 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMG-628862269-93-0AMG628AMG 628TRP ChannelTransient receptor potential channelsCHOorally active Sprague-Dawley ratInhibitorinhibitorinhibit

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