2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. AMG0347

AMG0347 is a transient receptor potential type V1 receptor antagonist. AMG0347 inhibits activation of the rat TRPV1 channel by heat (IC50 = 0.2 nm), protons (IC50= 0.8 nm), or capsaicin (IC50 = 0.7 nm).

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AMG0347 Chemical Structure

AMG0347 Chemical Structure

CAS No. : 946615-43-6

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Description

AMG0347 is a transient receptor potential type V1 receptor antagonist. AMG0347 inhibits activation of the rat TRPV1 channel by heat (IC50 = 0.2 nm), protons (IC50= 0.8 nm), or capsaicin (IC50 = 0.7 nm)[1].

Molecular Weight

445.48

Formula

C24H26F3N3O2
CAS No.
SMILES

O=C(NC1=C2CC(O)CCC2=CC=C1)/C=C/C3=CC=C(C(F)(F)F)N=C3N4CCCCC4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AMG0347 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMG0347946615-43-6AMG 0347AMG-0347TRP ChannelTransient receptor potential channelsTRP Channel antagonistInhibitorinhibitorinhibit

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