Amilo-5MER TFA  (Synonyms: 5-MP TFA)

Amilo-5MER (5-MP) (TFA) is an orally active and selective Serum Amyloid A (SAA) inhibitor. Amilo-5MER (TFA) specifically inhibits the release of pro-inflammatory cytokines IL-6 and IL-1β from SAA-activated cells. Amilo-5MER (TFA) reduces chronic inflammation and relieves symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). Amilo-5MER (TFA) is promising for research of autoimmune diseases and chronic inflammatory diseases^[1].

576.66 (free base)

C₂₃H₄₀N₆O₉S.xC₂HF₃O₂

Solid

White to off-white

Ac-Met-Thr-Ala-Asp-Val-NH2

Ac-MTADV-NH2

CC(C)[C@@H](C(N)=O)NC([C@H](CC(O)=O)NC([C@H](C)NC([C@H]([C@H](O)C)NC([C@@H](NC(C)=O)CCSC)=O)=O)=O)=O.O=C(C(F)(F)F)O.[x]

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Hemed-Shaked M, et al. MTADV 5-MER peptide suppresses chronic inflammations as well as autoimmune pathologies and unveils a new potential target-Serum Amyloid A. J Autoimmun. 2021 Nov;124:102713.  [Content Brief]