Amine-PEG4-Desthiobiotin

Name: Amine-PEG4-Desthiobiotin
Brand: MedChemExpress
SKU: HY-134720
Rating: 4.5 (1 reviews)

Cat. No.: HY-134720 Purity: 99.23%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Amine-PEG4-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Amine-PEG4-Desthiobiotin Chemical Structure

CAS No. : 2306109-91-9

Size	Price	Stock	Quantity
10 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Amine-PEG4-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

432.55

Formula

C₂₀H₄₀N₄O₆

CAS No.

2306109-91-9

Appearance

Liquid (Density: 1.078±0.06 g/cm³)

Color

Colorless to light yellow

SMILES

O=C(NCCOCCOCCOCCOCCN)CCCCC[C@H]([C@H](C)N1)NC1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 250 mg/mL (577.97 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3119 mL	11.5594 mL	23.1187 mL
5 mM	0.4624 mL	2.3119 mL	4.6237 mL
10 mM	0.2312 mL	1.1559 mL	2.3119 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.23%

Select Batch:

Data Sheet (266 KB) SDS (394 KB)

COA (240 KB) HNMR (277 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3119 mL	11.5594 mL	23.1187 mL	57.7968 mL
	5 mM	0.4624 mL	2.3119 mL	4.6237 mL	11.5594 mL
	10 mM	0.2312 mL	1.1559 mL	2.3119 mL	5.7797 mL
	15 mM	0.1541 mL	0.7706 mL	1.5412 mL	3.8531 mL
	20 mM	0.1156 mL	0.5780 mL	1.1559 mL	2.8898 mL
	25 mM	0.0925 mL	0.4624 mL	0.9247 mL	2.3119 mL
	30 mM	0.0771 mL	0.3853 mL	0.7706 mL	1.9266 mL
	40 mM	0.0578 mL	0.2890 mL	0.5780 mL	1.4449 mL
	50 mM	0.0462 mL	0.2312 mL	0.4624 mL	1.1559 mL
	60 mM	0.0385 mL	0.1927 mL	0.3853 mL	0.9633 mL
	80 mM	0.0289 mL	0.1445 mL	0.2890 mL	0.7225 mL
	100 mM	0.0231 mL	0.1156 mL	0.2312 mL	0.5780 mL