Amino-PEG7-C2-SH hydrochloride

Name: Amino-PEG7-C2-SH hydrochloride
Brand: MedChemExpress
SKU: HY-138451
Rating: 4.5 (1 reviews)

Cat. No.: HY-138451 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Amino-PEG7-C2-SH hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Amino-PEG7-C2-SH hydrochloride Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Amino-PEG7-C2-SH hydrochloride:

HS-PEG7-CH2CH2NH2 Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Amino-PEG7-C2-SH hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

421.98

Formula

C₁₆H₃₆ClNO₇S

Appearance

Liquid

Color

Light yellow to yellow

SMILES

SCCOCCOCCOCCOCCOCCOCCOCCN.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 250 mg/mL (592.45 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3698 mL	11.8489 mL	23.6978 mL
5 mM	0.4740 mL	2.3698 mL	4.7396 mL
10 mM	0.2370 mL	1.1849 mL	2.3698 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (244 KB) HNMR (259 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3698 mL	11.8489 mL	23.6978 mL	59.2445 mL
	5 mM	0.4740 mL	2.3698 mL	4.7396 mL	11.8489 mL
	10 mM	0.2370 mL	1.1849 mL	2.3698 mL	5.9245 mL
	15 mM	0.1580 mL	0.7899 mL	1.5799 mL	3.9496 mL
	20 mM	0.1185 mL	0.5924 mL	1.1849 mL	2.9622 mL
	25 mM	0.0948 mL	0.4740 mL	0.9479 mL	2.3698 mL
	30 mM	0.0790 mL	0.3950 mL	0.7899 mL	1.9748 mL
	40 mM	0.0592 mL	0.2962 mL	0.5924 mL	1.4811 mL
	50 mM	0.0474 mL	0.2370 mL	0.4740 mL	1.1849 mL
	60 mM	0.0395 mL	0.1975 mL	0.3950 mL	0.9874 mL
	80 mM	0.0296 mL	0.1481 mL	0.2962 mL	0.7406 mL
	100 mM	0.0237 mL	0.1185 mL	0.2370 mL	0.5924 mL