1. PROTAC
  2. PROTAC Linkers
  3. Amino-PEG7-C2-SH hydrochloride

Amino-PEG7-C2-SH hydrochloride 

Cat. No.: HY-138451 Purity: ≥98.0%
SDS COA Handling Instructions

Amino-PEG7-C2-SH hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Amino-PEG7-C2-SH hydrochloride Chemical Structure

Amino-PEG7-C2-SH hydrochloride Chemical Structure

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Amino-PEG7-C2-SH hydrochloride:

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Description

Amino-PEG7-C2-SH hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

421.98

Formula

C16H36ClNO7S

Appearance

Liquid

Color

Light yellow to yellow

SMILES

SCCOCCOCCOCCOCCOCCOCCOCCN.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (592.45 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3698 mL 11.8489 mL 23.6978 mL
5 mM 0.4740 mL 2.3698 mL 4.7396 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3698 mL 11.8489 mL 23.6978 mL 59.2445 mL
5 mM 0.4740 mL 2.3698 mL 4.7396 mL 11.8489 mL
10 mM 0.2370 mL 1.1849 mL 2.3698 mL 5.9245 mL
15 mM 0.1580 mL 0.7899 mL 1.5799 mL 3.9496 mL
20 mM 0.1185 mL 0.5924 mL 1.1849 mL 2.9622 mL
25 mM 0.0948 mL 0.4740 mL 0.9479 mL 2.3698 mL
30 mM 0.0790 mL 0.3950 mL 0.7899 mL 1.9748 mL
40 mM 0.0592 mL 0.2962 mL 0.5924 mL 1.4811 mL
50 mM 0.0474 mL 0.2370 mL 0.4740 mL 1.1849 mL
60 mM 0.0395 mL 0.1975 mL 0.3950 mL 0.9874 mL
80 mM 0.0296 mL 0.1481 mL 0.2962 mL 0.7406 mL
100 mM 0.0237 mL 0.1185 mL 0.2370 mL 0.5924 mL
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Amino-PEG7-C2-SH hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Amino-PEG7-C2-SH hydrochloride
Cat. No.:
HY-138451
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