Amorfrutin B

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Amorfrutin B is a highly potent natural peroxisome proliferation-activated receptor γ (PPARγ) agonist with oral activity with K_i values of 19 nM and EC₅₀ values of 73 nM, respectively. Amorfrutin B has hypoglycemic and neuroprotective activities.

For research use only. We do not sell to patients.

Amorfrutin B Chemical Structure

CAS No. : 78916-42-4

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Description

In Vitro

Amorfrutin B (1,5 μM, 6 h) inhibits apoptosis and autophagy by gene methylation and miRNA-dependent regulation, and protects mouse brain neurons from hypoxia/ischemia^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Amorfrutin B (100 mg/kg, added to food for 2 weeks) improves insulin sensitivity, glucose tolerance and lipid concentration in insulin-resistant mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	High-fat diet mice model^[2].
Dosage:	100 mg/kg
Administration:	Add to food，2 weeks
Result:	Reduced fasting plasma levels of triacylglycerols by 25% and the concentrations of deleterious plasma NEFA by 29%.

Molecular Weight

408.53

Formula

C₂₆H₃₂O₄

CAS No.

78916-42-4

SMILES

O=C(O)C1=C(CCC2=CC=CC=C2)C=C(OC)C(C/C=C(C)/CC/C=C(C)\C)=C1O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Przepiórska K, et al. Amorfrutin B Protects Mouse Brain Neurons from Hypoxia/Ischemia by Inhibiting Apoptosis and Autophagy Processes Through Gene Methylation- and miRNA-Dependent Regulation. Mol Neurobiol. 2023 Feb;60(2):576-595. [Content Brief]

[2]. Weidner C, et al. Amorfrutin B is an efficient natural peroxisome proliferator-activated receptor gamma (PPARγ) agonist with potent glucose-lowering properties. Diabetologia. 2013 Aug;56(8):1802-12. [Content Brief]

Amorfrutin B Related Classifications

Neurological Disease Metabolic Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amorfrutin B78916-42-4PPARPeroxisome proliferator-activated receptorsPPARγHFDHypoglycemicNeuroprotectiveInhibitorinhibitorinhibit

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