AMP-579 

AMP-579 is an adenosine receptor agonist that primarily targets adenosine A1 and A2_A receptors (with K_i values of 1.7 and 4.5 nM for the A1 receptor in rat brain and adipocytes, and a K_i value of 56 nM for the A2_A receptor in rat brain). AMP-579 inhibits lipolysis, restores insulin-dependent glucose transport, and reduces heart rate through the activation of A1 receptors, while it induces vasodilation, particularly in coronary arteries, through the activation of A2_A receptors (with an IC₅₀ of 0.3 μM in porcine coronary arterial rings). AMP 579 shows potential for application in cardioprotection and the treatment of acute myocardial infarction^[1].

478.01

C₂₂H₂₈ClN₅O₃S

213453-89-5

O[C@H]1[C@@H](C[C@@H]([C@H]1O)C(NCC)=O)N2C3=NC=NC(N[C@H](CC)CC4=C(C=CS4)Cl)=C3C=C2

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• [1]. Merkel L, et al. Pharmacological characterization of AMP 579, a novel adenosine A1/A2 receptor agonist and cardioprotective[J]. Drug development research, 1998, 45(1): 30-43.