AMRI-59

Cat. No.: HY-111125: FAQs
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AMRI-59 is a potent inhibitor of PrxI used for parasitic infections. AMRI-59 can increase cellular ROS, leading to activation of signaling pathways mediated by mitochondria and apoptosis signal-regulated kinase 1, thereby leading to apoptosis in A549 human lung adenocarcinoma. AMRI-59 exhibits significant antitumor activity without apparent acute toxicity.

For research use only. We do not sell to patients.

AMRI-59 Chemical Structure

CAS No. : 923515-92-8

Size	Price	Stock
1 mg	USD 205	Ask For Quote & Lead Time
5 mg	USD 460	Ask For Quote & Lead Time
10 mg	USD 680	Ask For Quote & Lead Time

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Description	AMRI-59 is a potent inhibitor of PrxI used for parasitic infections. AMRI-59 can increase cellular ROS, leading to activation of signaling pathways mediated by mitochondria and apoptosis signal-regulated kinase 1, thereby leading to apoptosis in A549 human lung adenocarcinoma. AMRI-59 exhibits significant antitumor activity without apparent acute toxicity^[1].
IC₅₀ & Target	PrxI^[1]
Molecular Weight	401.50
Formula	C₂₅H₂₇N₃O₂
CAS No.	923515-92-8
SMILES	O=C(N1CCC(CC2=CC=C(N3C=CC=C3)C=C2)CC1)NC4=CC=CC(C(C)=O)=C4
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (265 KB) Handling Instructions (2659 KB)
References	[1]. Yang YJ, et al. Effective Killing of Cancer Cells Through ROS-Mediated Mechanisms by AMRI-59 Targeting Peroxiredoxin I. Antioxid Redox Signal. 2016 Mar 10;24(8):453-69. [Content Brief]

AMRI-59 Related Classifications

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	×		=		×
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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMRI-59923515-92-8AMRI59AMRI 59ParasiteReactive Oxygen SpeciesApoptosisParasitic infectionmitochondrial damageapoptosisInhibitorinhibitorinhibit

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AMRI-59

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