2. GPCR/G Protein Immunology/Inflammation
  3. Prostaglandin Receptor COX NO Synthase
  4. Amtolmetin guacil

Amtolmetin guacil is an effective nonsteroidal anti-Inflammatory agent with pain-relieving effects. Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase (COX). Amtolmetin guacil can stimulate capsaicin receptors present on the gastrointestinal wall and also releases gastroprotective nitric oxide (NO). Amtolmetin guacil can be used to research knee osteoarthritis.

For research use only. We do not sell to patients.

Amtolmetin guacil Chemical Structure

Amtolmetin guacil Chemical Structure

CAS No. : 87344-06-7

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Based on 1 publication(s) in Google Scholar

Amtolmetin guacil Related Antibodies

Top Publications Citing Use of Products

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DP EP FP IP TXA2/TP TXB2

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COX COX-1 COX-2 COX-3

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nNOS iNOS eNOS

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Description

Amtolmetin guacil is an effective nonsteroidal anti-Inflammatory agent with pain-relieving effects. Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase (COX). Amtolmetin guacil can stimulate capsaicin receptors present on the gastrointestinal wall and also releases gastroprotective nitric oxide (NO). Amtolmetin guacil can be used to research knee osteoarthritis[1][2].

IC50 & Target

Prostaglandin receptor, COX, NO[1][2]
In Vitro

Amtolmetin guacil (100 μM; 0-60 min) converts to TMT (Tolmetin, HY-B1799) along with MED5 (1-methyl-5-p-methylbenzoyl-pyrrol-2-acetamido aceticacid) in rat fresh plasma and rat liver microsomal, rapidly converts to MED5 and MED5 methyl ester without yielding TMT in human fresh plasma and human liver microsomes[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Amtolmetin guacil Related Antibodies
In Vivo
Animal Model: Male Wistar rats[3]
Dosage: 50 mg/kg
Administration: p.o.; single dosage
Result: Pharmacokinetic Parameters of Amtolmetin guacil in male Wistar rats[3].
AUC0-t (ng/mL·h) AUC0-∞ (ng/mL·h) Cmax (μg/mL) Tmax (h) Kel (h-1) t1/2,β (h)
TMT following Amtolmetin guacil dosing 162 ± 21.49 164 ± 22.47 81.62 ± 5.02 0.50 ± 0.00 0.28 ± 0.00 2.41 ± 0.01
Molecular Weight

420.46

Formula

C24H24N2O5
CAS No.
SMILES

O=C(C1=CC=C(C)C=C1)C2=CC=C(CC(NCC(OC3=C(C=CC=C3)OC)=O)=O)N2C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Amtolmetin guacil Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amtolmetin guacil87344-06-7Prostaglandin ReceptorCOXNO SynthaseCyclooxygenaseNitric oxide synthasesNOSnonsteroidalanti-Inflammatorypain-relievingknee osteoarthritiscapsaicin receptorsTolmetinInhibitorinhibitorinhibit

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