2. Anti-infection
  3. SARS-CoV
  4. Amubarvimab

Amubarvimab  (Synonyms: BRII-196)

Cat. No.: HY-P99435 Purity: 95.00%
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Amubarvimab (BRII-196) is a human IgG1 mAb that bind to non-competing epitopes on the receptor binding domain (RBD) of spike protein, with a KD of 5.88 nM. Amubarvimab can effectively neutralize SARS-CoV-2 variants.

For research use only. We do not sell to patients.

CAS No. : 2509447-07-6

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Based on 1 publication(s) in Google Scholar

Amubarvimab Related Antibodies

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Description

Amubarvimab (BRII-196) is a human IgG1 mAb that bind to non-competing epitopes on the receptor binding domain (RBD) of spike protein, with a KD of 5.88 nM. Amubarvimab can effectively neutralize SARS-CoV-2 variants[1][2].
Isotype

Human IgG1 kappa
Recommend Isotype Controls
In Vitro

Amubarvimab shows specific activity against wild-type SARS-CoV-2 and no cross-reactivity against other coronaviruses[1].
Amubarvimab binds to two regions spanning amino acids 453-505 in the receptor-binding motif (RBM) and amino acids residues 403-421 in the core region of RBD[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Amubarvimab Related Antibodies
In Vivo

Amubarvimab (10-50 mg/kg; i.p.) in combination with romlusevimab significantly decreases viral load in the lungs, and reduces lung pathology in a Syrian golden hamster model of SARS-CoV-2 infection[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Amubarvimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation
References
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Amubarvimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amubarvimab2509447-07-6BRII-196BRII196BRII 196SARS-CoVSARS coronavirusIgG1receptor binding domainRBDspike proteinSARS-CoV-2Inhibitorinhibitorinhibit

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