2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. AN317

AN317 is a selective agonist for α6β2-containing nicotinic acetylcholine receptor (nAChR) with Ki of 6.2 nM and 4.1 nM, for α6/α3β2β3 receptor and α4β2 receptor, respectively. AN317 induces dopamine release in the synaptosomes of the rat striatum, enhances dopaminergic neuronal activity in substantia nigra, and exhibits protective efficacy to rat neurons against dopamine neurotoxin MPP+. AN317 exhibits good pharmacokinetic characteristics in rats. AN317 penetrates the blood-brain barrier (BB).

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AN317 Chemical Structure

AN317 Chemical Structure

CAS No. : 946074-35-7

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Description

AN317 is a selective agonist for α6β2-containing nicotinic acetylcholine receptor (nAChR) with Ki of 6.2 nM and 4.1 nM, for α6/α3β2β3 receptor and α4β2 receptor, respectively. AN317 induces dopamine release in the synaptosomes of the rat striatum, enhances dopaminergic neuronal activity in substantia nigra, and exhibits protective efficacy to rat neurons against dopamine neurotoxin MPP+. AN317 exhibits good pharmacokinetic characteristics in rats. AN317 penetrates the blood-brain barrier (BB)[1].

IC50 & Target

Ki: 6.2 nM (α6/α3β2β3 nAChR), 4.1 nM (α4β2 nAChR)
Molecular Weight

217.31

Formula

C13H19N3
CAS No.
SMILES

CN(C(CCC1)C2)C1CN2C3=CC=CN=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AN317 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AN317946074-35-7AN 317AN-317nAChRNicotinic acetylcholine receptorsTE671HEK293Sprague-Dawley ratParkinson’s diseaseBBB penetrateInhibitorinhibitorinhibit

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