Androgen receptor antagonist 7 

Androgen receptor antagonist 7 is an effective androgen receptor (AR) antagonist with an IC₅₀ value of 1.18 µM. Androgen receptor antagonist 7 has biological activity in vitro and inhibits the expression of AR target in a time and dose dependent manner with an GI₅₀ value of 7.9 µM ^[1].

IC50: 1.18 µM^[1]

Androgen receptor antagonist 7 (compound 3d) (10 µM; 24 h) significantly reduces the expression level of AR protein^[1].
Androgen receptor antagonist 7 (20 µM; 72 h) inhibits the proliferation of LAPC-4 and 22Rv1 cells^[1].
Androgen receptor antagonist 7 (0-20 µM; 24, 48 and 72 h) inhibits the expression of AR in a time and dose dependent manner without inducing apoptosis^[1].
Androgen receptor antagonist 7 (10 µM; 3 d) targets AR in vitro and reduces the expression of AR^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

422.58

C₂₇H₃₅FN₂O

2409791-89-3

[H][C@@]12CC[C@]3([C@@]4(CC[C@@H]([C@]4(CC[C@@]3([C@]1(CC5=C(N(N=C5C2)C6=CC=C(C=C6)F)C)C)[H])C)O)[H])[H]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Peřina M, et al. A-ring-fused pyrazoles of dihydrotestosterone targeting prostate cancer cells via the downregulation of the androgen receptor. Eur J Med Chem. 2023 Jan 13;249:115086.  [Content Brief]