Angiogenesis inhibitor 2

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Angiogenesis inhibitor 2 (compound 72) is a potent angiogenesis inhibitor. Angiogenesis inhibitor 2 inhibits the proliferation of HUVEC and HCT-15 cells, with IC₅₀ values of 1.93 and 0.21 μM. Angiogenesis inhibitor 2 induces the apoptosis of HUVEC and HCT-15 cells. Angiogenesis inhibitor 2 shows anticancer activity, and suppresses the invasion of cancer cells. Angiogenesis inhibitor 2 inhibits the angiogenesis in zebrafish embryos.

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Angiogenesis inhibitor 2 Chemical Structure

CAS No. : 2151067-32-0

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEL	IC₅₀	4.22 μM Compound: 4c	Cytotoxicity against human HEL cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HEL cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 29133049]
K562	IC₅₀	3.19 μM Compound: 4c	Cytotoxicity against human K562 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human K562 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 29133049]
MDA-MB-231	IC₅₀	5.57 μM Compound: 4c	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 29133049]
PC-3	IC₅₀	2.1 μM Compound: 4c	Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 29133049]

Molecular Weight

738.93

Formula

C₄₂H₅₀N₄O₆S

CAS No.

2151067-32-0

SMILES

COC1=C2C3=C(C=C1OC)CCN(C)[C@@]3([H])CC4=C(C=C(C(OC5=CC=C(C[C@@]6([H])C7=CC(O2)=C(C=C7CCN6C)OC)C=C5)=C4)OC)NC(NC(C)C)=S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang RH, et al. Discovery of tetrandrine derivatives as tumor migration, invasion and angiogenesis inhibitors. Bioorg Chem. 2020 Aug;101:104025. [Content Brief]