Angiotensin II type 1 receptor (181-187)

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Angiotensin II type 1 receptor (181-187) is a 9-amino acid sequence of the second extracellular loop of angiotensin II (Ang II) in the renin-angiotensin system. Angiotensin II type 1 receptor (181-187) serves as the localization epitope of angiotensin II receptor autoantibodies (AT1RaAb) and is used to detect and quantify AT1RaAb levels in serum.

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Angiotensin II type 1 receptor (181-187) Chemical Structure

CAS No. : 275359-37-0

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Description	Angiotensin II type 1 receptor (181-187) is a 9-amino acid sequence of the second extracellular loop of angiotensin II (Ang II) in the renin-angiotensin system. Angiotensin II type 1 receptor (181-187) serves as the localization epitope of angiotensin II receptor autoantibodies (AT1RaAb) and is used to detect and quantify AT1RaAb levels in serum^[1].
Molecular Weight	880.90
Formula	C₄₀H₅₂N₁₀O₁₃
CAS No.	275359-37-0
Sequence	Ala-Phe-His-Tyr-Glu-Ser-Gln
Sequence Shortening	AFHYESQ
SMILES	OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@H](C(O)=O)CCC(N)=O)=O)=O)=O)NC([C@@H](NC([C@@H](NC([C@@H](N)C)=O)CC2=CC=CC=C2)=O)CC3=CN=CN3)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (257 KB) Handling Instructions (2659 KB)
References	[1]. Abadir, et al. "Discovery and validation of agonistic angiotensin receptor autoantibodies as biomarkers of adverse outcomes." Circulation 135.5 (2017): 449-459. [Content Brief]