2. Anti-infection
  3. Parasite
  4. Anti-infective agent 5

Anti-infective agent 5 (compound 74) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.10 μM. Anti-infective agent 5 effectively reduces parasite burden in vivo. Anti-infective agent 5 can be used for the research of infection.

For research use only. We do not sell to patients.

Anti-infective agent 5 Chemical Structure

Anti-infective agent 5 Chemical Structure

CAS No. : 2738381-47-8

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Anti-infective agent 5 Related Antibodies

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Description

Anti-infective agent 5 (compound 74) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.10 μM. Anti-infective agent 5 effectively reduces parasite burden in vivo. Anti-infective agent 5 can be used for the research of infection[1].

IC50 & Target

Trypanosoma

 

Cellular Effect
Cell Line Type Value Description References
HEK293 CC50
> 92 μM
Compound: 34e
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 20 hrs
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 20 hrs
[PMID: 33151678]
In Vitro

Anti-infective agent 5 (0.1 nM-100 μM; 48 h) shows antitrypanosomal activity against T. cruzi amastigotes in 3T3 cells with an IC50 value of 0.10 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-infective agent 5 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: 3T3 cell line
Concentration: 0.1 nM-100 μM
Incubation Time: 48 hours
Result: Showed activity against 3T3 cells with an CC50 value of ＞37 μM.
In Vivo

Anti-infective agent 5 (50 mg/kg; p.o. twice daily for five days) reduces the parasite burden in bioluminescent T. cruzi mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice with bioluminescent T. cruzi CL Brener parasites infection[1]
Dosage: 50 mg/kg
Administration: Oral gavage; 50 mg/kg twice daily for five days
Result: Showed a reduction in parasite burden of >98-99% with no significant adverse effects observed in mice.
Molecular Weight

347.33

Formula

C18H13N5O3
CAS No.
SMILES

O=C1C2=NC([N+]([O-])=O)=CN2C=CN1CC3=CC=C(C=C3)C4=CC=CN=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-infective agent 5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-infective agent 52738381-47-8Parasitenitroimidazopyrazinoneoralanti-infective3T3parasitemiceCYPInhibitorinhibitorinhibit

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