2. Anti-infection Apoptosis
  3. Bacterial TNF Receptor
  4. Anti-inflammatory agent 15

Anti-inflammatory agent 15 (compound 29) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 15 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 2.3 and 7.8 μM, respectively. Anti-inflammatory agent 15 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 15 can be used for tuberculosis (TB) research.

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Anti-inflammatory agent 15 Chemical Structure

Anti-inflammatory agent 15 Chemical Structure

CAS No. : 474516-87-5

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Anti-inflammatory agent 15 Related Antibodies

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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Description

Anti-inflammatory agent 15 (compound 29) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 15 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 2.3 and 7.8 μM, respectively. Anti-inflammatory agent 15 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 15 can be used for tuberculosis (TB) research[1].

IC50 & Target

MIC50: 2.3 ± 1.6 μM (Mtb H37Rv), 7.8 ± 0.8 μM (Mtb M299); IC50: 2.4 ± 0.4 μM (NO)[1]
Cellular Effect
Cell Line Type Value Description References
RAW264.7 CC50
120.8 μM
Compound: 29
Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
[PMID: 34890996]
RAW264.7 IC50
2.4 μM
Compound: 29
Inhibition of NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based analysis
Inhibition of NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based analysis
[PMID: 34890996]
RAW264.7 IC50
4 μM
Compound: 29
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in TNFalpha protein expression level after 24 hrs by ELISA
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in TNFalpha protein expression level after 24 hrs by ELISA
[PMID: 34890996]
RAW264.7 IC50
55.7 μM
Compound: 29
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in IL1beta protein expression level after 24 hrs by ELISA
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in IL1beta protein expression level after 24 hrs by ELISA
[PMID: 34890996]
In Vitro

Anti-inflammatory agent 15 (compound 29) is active in the reduction of accumulated nitrite, with an IC50 of 71.7 ± 1.1 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 15 Related Antibodies
Molecular Weight

284.42

Formula

C17H20N2S
CAS No.
SMILES

S=C(NCC1=CC=CC=C1)NC2=CC=C(C(C)C)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-inflammatory agent 15 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 15474516-87-5BacterialTNF ReceptorTumor Necrosis Factor ReceptorTNFRthiourea derivativeantimycobacterialanti-inflammatorylow cytotoxicityTuberculosisTBMtb H37RvMtb M299MycobacteriumbacterialInhibitorinhibitorinhibit

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