Anti-inflammatory agent 33 

Anti-inflammatory agent 33 is a potent p38α inhibitor. Anti-inflammatory agent 33 inhibits NO production. Anti-inflammatory agent 33 inhibits LPS-induced iNOS, COX-2, p-p38α, p-MK2 protein expression. Anti-inflammatory agent 33 shows anti-inflammatory activity^[1].

Anti-inflammatory agent 33 (compound 8j) (10, 5, 2.5, 1.25, 0.675 μM; 1+24 h) significantly inhibits NO production with the inhibition rate of 93.97% and the IC₅₀ value of 1.25 µM in LPS-induced RAW264.7 cells^[1].
Anti-inflammatory agent 33 (1.25, 2.5, 5, 10, 20 µM; 1+24 h) inhibits the production of TNF-α and IL-1β with IC₅₀ values of 11.5, 8.48 μM, respectively^[1].
Anti-inflammatory agent 33 (1, 3, 5 µM; 1+24 h) inhibits LPS-induced iNOS, COX-2, p-p38α; p-MK2 protein expression in a dose-dependent manner in RAW264.7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 33 (10, 30 mg/kg; once a day for 14 days) shows anti-inflammatory activity in a dose-dependent manner in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

433.44

C₂₂H₁₅N₃O₅S

2816993-09-4

COC1=CC=C(C=C1)S(=O)(NC2=CC3=C(N=C4C(C5=CC=CC=C5N4C3=O)=O)C=C2)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Du J, et al. Novel tryptanthrin derivatives with benzenesulfonamide substituents: Design, synthesis, and anti-inflammatory evaluation. Eur J Med Chem. 2022 Nov 25;246:114956.  [Content Brief]