Anti-inflammatory agent 48 

Anti-inflammatory agent 48 is an anti-inflammatory agent based on its role in inhibiting the NF-κB signaling pathway and activating HO-1 expression^[1].

Anti-inflammatory agent 48 (compound 1) shows NO-inhibitory ability in LPS-induced RAW 264.7 macrophage cells. Anti-inflammatory agent 48 exhibits superior NF-κB-inhibitory ability compared to Diclofenac through the activation of Nrf2/HO-1 signaling pathway in RAW 264.7^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 48 (compound 1; 20 mg/kg) results in remarkable colitis improvement in dextran sulfate sodium (DSS)-induced mice model by up-regulating HO-1 and down-regulating phosphorylation level of NF-κB p65^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

442.33

C₂₄H₂₁Cl₂NO₃

ClC1=CC=CC(Cl)=C1NC2=CC=CC=C2CC(OC3=C(OC)C=C(CC=C)C=C3)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wei Wang, et al. Diclofenac and eugenol hybrid with enhanced anti-inflammatory activity through activating HO-1 and inhibiting NF-κB pathway in vitro and in vivo. Eur J Med Chem. 2023 Nov 5;259:115669.  [Content Brief]