Anti-inflammatory agent 50 

Anti-inflammatory agent 50 (compound a1) is a Fusidic acid derivative with anti-inflammatory effects. Anti-inflammatory agent 50 inhibits inflammatory factor NO, IL-6 and TNF-α. Anti-inflammatory agent 50 alleviates acute lung injury by regulating inflammatory mediators and suppressing the MAPK, NF-κB and NLRP3 inflammasome signaling pathways^[1].

In LPS-induced RAW264.7 cells, Anti-inflammatory agent 50 (compound a1) inhibits inflammatory factor NO (IC₅₀ of 3.26 μM), IL-6 (IC₅₀ of 1.85 μM) and TNF-α (IC₅₀ of 3.88 μM). Anti-inflammatory agent 50 markedly inhibits the expression of certain immune-related cytotoxic factors, including COX-2 and inducible nitric-oxide synthase (iNOS)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 50 (compound a1) can reduce lung inflammation and NO, IL-6, TNF-α, COX-2 and iNOS in LPS-induced acute lung injury (ALI) mice. Anti-inflammatory agent 50 (compound a1) inhibits the mitogen-activated protein kinase (MAPK) signaling pathway by down-regulating the phosphorylation of p38 MAPK, c-JNK and ERK. Moreover, Anti-inflammatory agent 50 also suppressing the phosphorylation of inhibitory NF-κB inhibitor α (IκBα) inhibits the activation of the NF-κB signaling pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

673.88

C₄₀H₅₅N₃O₆

C/C(C)=C\CC/C(C(OCC1=CN(C2=CC=CC=C2)N=N1)=O)=C3[C@@H](OC(C)=O)C[C@]4(C)[C@@]5(C)CC[C@@]6([H])[C@H](C)[C@H](O)CC[C@]6(C)C5[C@H](O)C[C@@]/34[H]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zheng Liu, et al. Design, synthesis fusidic acid derivatives alleviate acute lung injury via inhibiting MAPK/NF-κB/NLRP3 pathway. Eur J Med Chem. 2023 Aug 1;259:115697.  [Content Brief]