Anti-inflammatory agent 53 

Anti-inflammatory agent 53 (compound 7c) is an orally active selective COX-2 inhibitor. Anti-inflammatory agent 52 has anti-HT29 transfer activity, which leads to periodic arrest in S phase and G2/M phase. Anti-inflammatory agent 52 has safety, moderate ability to suppress inflammation. Anti-inflammatory agent 52 has a rare property of suppressing the development of tumor in mouse model, showing anti-cancer activity^[1].

COX-2^[1]

Anti-inflammatory agent 53 (compound 7c) (0.025 μM; 24 h) inhibits colonies formation of HT29 cells, arrests cell cycle at G2/M and S phase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 53 (compound 7c) (50 mg/kg; po; every other day for two weeks) decreasses the volume and weight of the tumors in Ehrlich solid carcinoma-bearing mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

434.51

C₂₄H₂₂N₂O₄S

O=C(NC1=CC=C(OC)C=C1)COC2=CC=C(N3C(C4=CC=CC=C4)SCC3=O)C=C2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Shawky AM, et al. Discovery and optimization of 2,3-diaryl-1,3-thiazolidin-4-one-based derivatives as potent and selective cytotoxic agents with anti-inflammatory activity. Eur J Med Chem. 2023 Nov 5;259:115712.  [Content Brief]