Anti-inflammatory agent 68 

Anti-inflammatory agent 68 (compound 7b) is a dual inhibitor of carbonic anhydrase and COX-2, a sulfonamide derivative of Polmacoxib (HY-16726), with anti-inflammatory properties and analgesic activity. Anti-inflammatory agent 68 has IC₅₀s of 12.6 μM and 60 nM for COX-1 and COX-2, respectively. The Ki of anti-inflammatory agent 68 binding to different isoforms of carbonic anhydrase are 52.6 nM (CA I), 79.1 nM (CA II), 58.1 nM (CA IX), and 17.2 nM (CA XII)^[1].

12.6 μM (COX-1), 60 nM (COX-2)^[1]
Ki: 52.6 nM (CA I), 79.1 nM (CA II), 58.1 nM (CA IX), 17.2 nM (CA XII)^[1]

359.38

C₁₂H₁₃N₃O₆S₂

O=S(OC(C=C1)=NN(C2=CC=C(S(=O)(N)=O)C=C2)C1=O)(CC)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Badawi WA, et al. Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2201407.  [Content Brief]