2. Others
  3. Others
  4. Anti-inflammatory agent 86

Anti-inflammatory agent 86 is a Chrysin (HY-14589) derivative with anti-inflammatory effects. Anti-inflammatory agent 86 inhibits monocyte adhesion to colon epithelium induced by TNF-α, with an IC50 of 4.71 μM. Anti-inflammatory agent 86 has the potential for the inflammatory bowel disease (IBD) research.

For research use only. We do not sell to patients.

Anti-inflammatory agent 86 Chemical Structure

Anti-inflammatory agent 86 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Anti-inflammatory agent 86 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Anti-inflammatory agent 86 is a Chrysin (HY-14589) derivative with anti-inflammatory effects. Anti-inflammatory agent 86 inhibits monocyte adhesion to colon epithelium induced by TNF-α, with an IC50 of 4.71 μM. Anti-inflammatory agent 86 has the potential for the inflammatory bowel disease (IBD) research[1].

In Vitro

Anti-inflammatory agent 86 (compound 4b) exhibits significant inhibitory activity against the adhesion of monocytes to HT-29 cells induced by TNF-α, with an IC50 value of 4.71 μM[1].
Anti-inflammatory agent 86 (5-10 μM; 4 h) significantly suppresses the expression of MCP-1 in a concentration-dependent manner. Anti-inflammatory agent 86 inhibits NF-κB activity in HT-29 cells in a dose-dependent manner[1].
Anti-inflammatory agent 86 (5-10 μM) demonstrates a notable inhibitory effect on the generation of ROS induced by TNF-α in a dose-dependent fashion[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 86 Related Antibodies

Western Blot Analysis[1]

Cell Line: TNF-α-stimulated HT-29 cells
Concentration: 5 μM, 10 μM
Incubation Time: Pretreatment with 1 h and then treat for 3 hours
Result: Effectively suppressed TNF-α-induced intercellular adhesion molecule (ICAM)-1 expression in a manner.
In Vivo

Anti-inflammatory agent 86 (30-60 mg/kg; po; once daily; for 15 days) demonstrates the most significant efficacy in the treatment of TNBS-induced colitis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Sprague-Dawley (SD) rats bearing colitis (induced by 2, 4, 6-trinitrobenzenesulfonic acid (TNBS))[1].
Dosage: 30 mg/kg/day or 60 mg/kg/day (10% DMSO, 15% SBE-β-CD, and 75% saline)
Administration: po; once daily; for 15 days
Result: Exhibiteds a dose-dependent inhibition of 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats.
Molecular Weight

554.72

Formula

C29H34N2O5S2
SMILES

O=C(N1CCN(CCOC2=CC(OC(C3=CC=CC=C3)=CC4=O)=C4C(O)=C2)CC1)CCCCC5CCSS5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Anti-inflammatory agent 86 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 86OthersChrysinanti-inflammatory effectsTNF-αinflammatory bowel disease (IBD)Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Anti-inflammatory agent 86
Cat. No.:
HY-161757
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.