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  4. Anti-inflammatory agent 86

Anti-inflammatory agent 86 is a Chrysin (HY-14589) derivative with anti-inflammatory effects. Anti-inflammatory agent 86 inhibits monocyte adhesion to colon epithelium induced by TNF-α, with an IC50 of 4.71 μM. Anti-inflammatory agent 86 has the potential for the inflammatory bowel disease (IBD) research.

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Anti-inflammatory agent 86 Chemical Structure

Anti-inflammatory agent 86 Chemical Structure

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Anti-inflammatory agent 86 Related Antibodies

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Description

Anti-inflammatory agent 86 is a Chrysin (HY-14589) derivative with anti-inflammatory effects. Anti-inflammatory agent 86 inhibits monocyte adhesion to colon epithelium induced by TNF-α, with an IC50 of 4.71 μM. Anti-inflammatory agent 86 has the potential for the inflammatory bowel disease (IBD) research[1].

In Vitro

Anti-inflammatory agent 86 (compound 4b) exhibits significant inhibitory activity against the adhesion of monocytes to HT-29 cells induced by TNF-α, with an IC50 value of 4.71 μM[1].
Anti-inflammatory agent 86 (5-10 μM; 4 h) significantly suppresses the expression of MCP-1 in a concentration-dependent manner. Anti-inflammatory agent 86 inhibits NF-κB activity in HT-29 cells in a dose-dependent manner[1].
Anti-inflammatory agent 86 (5-10 μM) demonstrates a notable inhibitory effect on the generation of ROS induced by TNF-α in a dose-dependent fashion[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 86 Related Antibodies

Western Blot Analysis[1]

Cell Line: TNF-α-stimulated HT-29 cells
Concentration: 5 μM, 10 μM
Incubation Time: Pretreatment with 1 h and then treat for 3 hours
Result: Effectively suppressed TNF-α-induced intercellular adhesion molecule (ICAM)-1 expression in a manner.
In Vivo

Anti-inflammatory agent 86 (30-60 mg/kg; po; once daily; for 15 days) demonstrates the most significant efficacy in the treatment of TNBS-induced colitis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Sprague-Dawley (SD) rats bearing colitis (induced by 2, 4, 6-trinitrobenzenesulfonic acid (TNBS))[1].
Dosage: 30 mg/kg/day or 60 mg/kg/day (10% DMSO, 15% SBE-β-CD, and 75% saline)
Administration: po; once daily; for 15 days
Result: Exhibiteds a dose-dependent inhibition of 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats.
Molecular Weight

554.72

Formula

C29H34N2O5S2
SMILES

O=C(N1CCN(CCOC2=CC(OC(C3=CC=CC=C3)=CC4=O)=C4C(O)=C2)CC1)CCCCC5CCSS5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-inflammatory agent 86 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 86OthersChrysinanti-inflammatory effectsTNF-αinflammatory bowel disease (IBD)Inhibitorinhibitorinhibit

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Anti-inflammatory agent 86
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