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  4. Anti-inflammatory agent 89

Anti-inflammatory agent 89 (5c) inhibits all asthma features. Anti-inflammatory agent 89 exhibits a significative effect on the restoration of pulmonary structure and reduction of lung inflammation through both its corticosteroid and H2S releasing component, which is proming for research of Asthma.

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Anti-inflammatory agent 89 Chemical Structure

Anti-inflammatory agent 89 Chemical Structure

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Anti-inflammatory agent 89 Related Antibodies

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Description

Anti-inflammatory agent 89 (5c) inhibits all asthma features. Anti-inflammatory agent 89 exhibits a significative effect on the restoration of pulmonary structure and reduction of lung inflammation through both its corticosteroid and H2S releasing component, which is proming for research of Asthma[1].

In Vitro

Anti-inflammatory agent 89 (100 μM, 24 h) shows no reduction in cell viability in RBL-2H3 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 89 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: RBL-2H3 cells
Concentration: 100 μM
Incubation Time: 24 h
Result: Did not show any reduction in cell viability compared to the vehicle in RBL-2H3 cells.
In Vivo

Anti-inflammatory agent 89 (1-2 mg/kg, i.p., administrated 30 min before ovalbumin sensitization on days 0 and 7 for 21 days) inhibits asthma like features by acting on pulmonary inflammation in Ovalbumin (OVA) (HY-W250978) sensitized mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice (20 g, 8 weeks) of OVA sensitization[2]
Dosage: 1-2 mg/kg
Administration: i.p., administrated 30 min before ovalbumin sensitization on days 0 and 7 for 21 days
Result: Inhibited bronchial hyperreactivity in a dose-dependent manner and reduced pulmonary IL-13 levels that well correlate with bronchial reactivity in OVA (HY-W250978) sensitized mice. Reduced OVA-induced α-SMA over-expression and restored the structure of the alveolar septa, bronchial epithelium and airway smooth muscle in OVA (HY-W250978) sensitized mice.
Molecular Weight

569.71

Formula

C31H39NO7S
SMILES

O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H]5[C@@]4(C(COC(CSC#N)=O)=O)O[C@]([H])(C6CCCCC6)O5)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-inflammatory agent 89 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 89Othersasthmapulmonary structurelung inflammationcorticosteroidH2S releasing componentInhibitorinhibitorinhibit

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Anti-inflammatory agent 89
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