Anti-Influenza agent 3 

Anti-Influenza agent 3 (compound 11h) is a potent anti-influenza agent with EC₅₀ values of 3.29, 2.45 µM for A/HK/68 (H3N2, M2-WT), A/WSN/33 (H1N1, M2-S31N) strain, respectively. Anti-Influenza agent 3 shows low cytotoxicity for MDCK epithelial cells. Anti-Influenza agent 3 inhibits the M2 WT and S31N ion channel conductivity^[1].

EC₅₀: 3.29 µM (H3N2); 2.45 µM (H1N1)^[1].

Anti-Influenza agent 3 shows lowe cytotoxicity for MDCK epithelial cells with an TC₅₀ of >173.14 µM^[1].
Anti-Influenza agent 3 (100 µM) inhibits the M2 WT and S31N ion channel conductivity in 293 T-Rex cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

311.87

C₁₆H₂₂ClNOS

2481321-20-2

O/N=C(C1=CC(C)=C(Cl)S1)\[C@H](C[C@@H]2C[C@H]3C2(C)C)[C@@H]3C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Dong J, Xiao M, Ma Q, Zhang G, Zhao W, Kong M, Zhang Y, Qiu L, Hu W. Design and synthesis of pinane oxime derivatives as novel anti-influenza agents. Bioorg Chem. 2020 Sep;102:104106.  [Content Brief]