Anti-MRSA agent 10 

Anti-MRSA agent 10 (Compound 2d) is a Cephalosporin (HY-144229) derivative and exhibits antibacterial activity. Anti-MRSA agent 10 is slightly drug resistane and exhibits low cytotoxicity in cells HUVEC and HBZY-1^[1].

Anti-MRSA agent 10 reveals no significant cytotoxicity in sheep red blood cells, HUVECs and HBZY-1 cells, with a safe dose of more than 128 μg/mL^[1].
Anti-MRSA agent 10 is antibacterial active against Gram-negative Stenotrophomonas maltophilia and Staphylococcus aureus, Gram-positiveEscherichia coli and Stenotrophomonas maltophilia, and methicillin-resistant Staphylococcus aureus (MRSA) with MICs of 0.7, 4, 8, 8 and 2-4 μg/mL, respectively^[1].
Anti-MRSA agent 10 (0-128 μg/mL) inhibits cellular respiration and viability in bacteria S. aureus through targeting penicilin binding proteins (PBP), disrupting bacterial cell wall structure and promoting oxidative damage^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

743.77

C₃₀H₃₆F₃N₇O₈S₂

O=C1[C@@H](NC(/C(C2=CSC([NH3+])=N2)=N\OC)=O)[C@H]3SCC(C[N+]4=CC(C(NCCCCCCCC)=O)=CC=C4)=C(C([O-])=O)N31.[O-]C(C(F)(F)F)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Chen S, et al., Design, synthesis and antibacterial evaluation of low toxicity amphiphilic-cephalosporin derivatives. Eur J Med Chem. 2024 Mar 15;268:116293.  [Content Brief]