2. MAPK/ERK Pathway NF-κB
  3. p38 MAPK NF-κB RANKL/RANK
  4. Anti-osteoporosis agent-11

Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. Anti-osteoporosis agent-11 has the most significant inhibitory effect on osteoclast differentiation, with an IC50 value of 0.36 μM. In addition, Anti-osteoporosis agent-11 inhibits osteoclast formation, bone resorption, and the expression of osteoclast-specific genes by blocking rankl-induced mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways.

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Anti-osteoporosis agent-11 Chemical Structure

Anti-osteoporosis agent-11 Chemical Structure

CAS No. : 2869099-50-1

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Anti-osteoporosis agent-11 Related Antibodies

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Description

Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. Anti-osteoporosis agent-11 has the most significant inhibitory effect on osteoclast differentiation, with an IC50 value of 0.36 μM. In addition, Anti-osteoporosis agent-11 inhibits osteoclast formation, bone resorption, and the expression of osteoclast-specific genes by blocking rankl-induced mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways[1].

Molecular Weight

497.31

Formula

C23H17NO2Se2
CAS No.
SMILES

O=C1C([Se]C2=CC=CC=C2)=C(C(N1CC3=CC=CC=C3)=O)[Se]C4=CC=CC=C4
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Anti-osteoporosis agent-11 Related Classifications

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Keywords:

Anti-osteoporosis agent-112869099-50-1p38 MAPKNF-κBRANKL/RANKNuclear factor-κBNuclear factor-kappaBosteoclastsosteoporosisMAPKbone resorptioncell differentiationInhibitorinhibitorinhibit

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