2. NF-κB MAPK/ERK Pathway
  3. RANKL/RANK p38 MAPK NF-κB
  4. Anti-osteoporosis agent-8

Anti-osteoporosis agent-8 (Compound 4aa) is an inhibitor for RANKL, which inhibits RANKL-induced osteoclastogenesis and osteoclast differentiation (IC50 is 2.41 μM) in cells RAW264.7. Anti-osteoporosis agent-8 ameliorates bone loss in an ovariectomized (OVX) mice model.

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Anti-osteoporosis agent-8 Chemical Structure

Anti-osteoporosis agent-8 Chemical Structure

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Anti-osteoporosis agent-8 Related Antibodies

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Description

Anti-osteoporosis agent-8 (Compound 4aa) is an inhibitor for RANKL, which inhibits RANKL-induced osteoclastogenesis and osteoclast differentiation (IC50 is 2.41 μM) in cells RAW264.7. Anti-osteoporosis agent-8 ameliorates bone loss in an ovariectomized (OVX) mice model[1].

In Vitro

Anti-osteoporosis agent-8 (0-10 μM, 5 days) promotes osteoblast differentiation in cells MC3T3-E1 through activation of BMP2 signaling pathway[1].
Anti-osteoporosis agent-8 (5 μM, 6 h) inhibits the osteoclast-related genes expression, osteoclastogenesis, and osteoclastic bone resorption, though inhibition of MAPK and NF-κB-signaling pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-osteoporosis agent-8 Related Antibodies

Western Blot Analysis[1]

Cell Line: BMMS
Concentration: 5 μM
Incubation Time: 6 h
Result: Inhibited phosphorylation of p38, ERK, JNK, p65 and IκBα.

Real Time qPCR[1]

Cell Line: MC3T3-E1
Concentration: 0-10 μM
Incubation Time: 5 days
Result: Promoted expression of BMP2, Runx2 and Smad.
In Vivo

Anti-osteoporosis agent-8 (10 mg/kg, i.p., every 2 days for 8 weeks) prevents the ovariectomization induced bone loss in C57BL/6 mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ovariectomized C57BL/6 mice model[1]
Dosage: 10 mg/kg
Administration: i.p., every other days, for 8 weeks
Result: Reduced the bone loss, increased bone volume/total bone volume, trabecular thickness and trabecular number, without significant toxicity in mainly organs.
Molecular Weight

431.31

Formula

C18H19F3N2O2Se
SMILES

O=C(NC1=CC=CN=C1)[C@H]([Se]C2=CC=CC=C2)C(C)(OCC(F)(F)F)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-osteoporosis agent-8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-osteoporosis agent-8RANKL/RANKp38 MAPKNF-κBNuclear factor-κBNuclear factor-kappaBRAW264.7C57BL/6 miceMC3T3-E1BMMSInhibitorinhibitorinhibit

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