anti-TNBC agent-3

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anti-TNBC agent-3 (compound 3g) is an apoptosis inducer with anti-cancer cell proliferation activity. anti-TNBC agent-3 inhibits tumor growth and metastasis in triple-negative breast cancer (TNBC) xenograft models.

For research use only. We do not sell to patients.

anti-TNBC agent-3 Chemical Structure

CAS No. : 2422001-25-8

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Bcl-2

In Vitro

anti-TNBC agent-3 (compound 3g) inhibits K562 and HepG2 proliferation with IC₅₀s of 0.24 μM and 0.25 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

anti-TNBC agent-3 (compound 3g) (10 mg/kg, 20 mg/kg; ip) inhibits tumor growth and metastasis in a mouse triple-negative breast cancer (TNBC) xenograft model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

539.66

Formula

C₂₉H₃₉F₂N₇O

CAS No.

2422001-25-8

SMILES

OCCN1CCC(C2CCN(C3=NC(N(C4CCCC4)C=N5)=C5C(NCC6=CC(F)=C(F)C=C6)=N3)CC2)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang Q, et al. Synthesis and mechanism of action of new purine derivatives against triple negative breast cancer. Eur J Med Chem. 2023 Sep 7;261:115797.. . [Content Brief]

anti-TNBC agent-3 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

anti-TNBC agent-32422001-25-8Bcl-2 FamilyApoptosisInhibitorinhibitorinhibit

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