2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Reactive Oxygen Species Apoptosis
  4. Antiangiogenic agent 7

Antiangiogenic agent 7 (Compound 1) can induce cell apoptosis, increase Reactive Oxygen Species, and inhibit the intracellular enzyme thioredoxin reductase. Antiangiogenic agent 7 has anti-cancer activity, with an IC50 of 0.08-3.5 μM against cervical cancer cells HeLa, prostate cancer cells PC-3, and non-small cell lung cancer A549. Antiangiogenic agent 7 inhibits tumor growth in mouse xenograft models.

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Antiangiogenic agent 7 Chemical Structure

Antiangiogenic agent 7 Chemical Structure

CAS No. : 2527888-07-7

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Description

Antiangiogenic agent 7 (Compound 1) can induce cell apoptosis, increase Reactive Oxygen Species, and inhibit the intracellular enzyme thioredoxin reductase. Antiangiogenic agent 7 has anti-cancer activity, with an IC50 of 0.08-3.5 μM against cervical cancer cells HeLa, prostate cancer cells PC-3, and non-small cell lung cancer A549. Antiangiogenic agent 7 inhibits tumor growth in mouse xenograft models[1].

Molecular Weight

647.46

Formula

C24H26AuN3P2S
CAS No.
SMILES

S=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=C([Au][P@@]4(C5)CN(C6)C[N@]5C[N@@]6C4)C=CC=C3
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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Antiangiogenic agent 7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiangiogenic agent 72527888-07-7Antiangiogenic agent7Antiangiogenic agent-7Reactive Oxygen SpeciesApoptosisHeLaPC-3A549mouse xenograft modelsInhibitorinhibitorinhibit

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