Antibacterial agent 117

Name: Antibacterial agent 117
Brand: MedChemExpress
SKU: HY-W282615
Rating: 4.5 (1 reviews)

Cat. No.: HY-W282615 Purity: 98.01%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Antibacterial agent 117, triazole derivative, is an antibacterial agent. Antibacterial agent 117 has against R. prowazekii MetAP1 (RpMetAP1) activity with an IC₅₀ value of 15 μM. Antibacterial agent 117 also inhibits rickettsial growth and can be used for the research of infection.

For research use only. We do not sell to patients.

Antibacterial agent 117 Chemical Structure

CAS No. : 341944-06-7

Size	Price	Stock	Quantity
5 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

IC50: 15 μM (RpMetAP1)^[1]

In Vitro

Antibacterial agent 117 can inhibit RpMetAP1 with an IC₅₀ value of 15 μM^[1].
Antibacterial agent 117 (0.3 μM, 3 μM, 30 μM and 300 μM) stimulates endothelial cell (EC) metabolism and also inhibits rickettsial growth^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

240.71

Formula

C₉H₉ClN₄S

CAS No.

341944-06-7

Appearance

Solid

Color

White to off-white

SMILES

NC1=NNC(SCC2=CC=CC=C2Cl)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (415.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1544 mL	20.7719 mL	41.5438 mL
5 mM	0.8309 mL	4.1544 mL	8.3088 mL
10 mM	0.4154 mL	2.0772 mL	4.1544 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.01%

Select Batch:

Data Sheet (281 KB) SDS (393 KB)

COA (247 KB) HNMR (256 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Travis R Helgren, et al. Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents. Bioorg Med Chem [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.1544 mL	20.7719 mL	41.5438 mL	103.8594 mL
	5 mM	0.8309 mL	4.1544 mL	8.3088 mL	20.7719 mL
	10 mM	0.4154 mL	2.0772 mL	4.1544 mL	10.3859 mL
	15 mM	0.2770 mL	1.3848 mL	2.7696 mL	6.9240 mL
	20 mM	0.2077 mL	1.0386 mL	2.0772 mL	5.1930 mL
	25 mM	0.1662 mL	0.8309 mL	1.6618 mL	4.1544 mL
	30 mM	0.1385 mL	0.6924 mL	1.3848 mL	3.4620 mL
	40 mM	0.1039 mL	0.5193 mL	1.0386 mL	2.5965 mL
	50 mM	0.0831 mL	0.4154 mL	0.8309 mL	2.0772 mL
	60 mM	0.0692 mL	0.3462 mL	0.6924 mL	1.7310 mL
	80 mM	0.0519 mL	0.2596 mL	0.5193 mL	1.2982 mL
	100 mM	0.0415 mL	0.2077 mL	0.4154 mL	1.0386 mL