2. Anti-infection
  3. Bacterial
  4. Antibacterial agent 123

Antibacterial agent 123 (compound 111) is a potent membrane-disrupting agent to combat antibiotic-resistant Gram-positive bacteria.

For research use only. We do not sell to patients.

Antibacterial agent 123 Chemical Structure

Antibacterial agent 123 Chemical Structure

CAS No. : 2615254-55-0

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Antibacterial agent 123 Related Antibodies

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Description

Antibacterial agent 123 (compound 111) is a potent membrane-disrupting agent to combat antibiotic-resistant Gram-positive bacteria[1].

In Vitro

Antibacterial agent 123 (compound 111) shows excellent activity (MIC<0.0625 μg/mL) toward S. aureus strains[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 123 Related Antibodies
In Vivo

Antibacterial agent 123 (compound 111) (p.o. (10 mg/kg) and i.v. (0.5 mg/kg); once) exhibits favorable pharmacokinetics profiles[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CD-1 mice[1]
Dosage: 0.5 mg/kg, 10 mg/kg
Administration: p.o. (10 mg/kg) and i.v. (0.5 mg/kg); once (Pharmacokinetic Analysis)
Result: Pharmacokinetic Parameters of Antibacterial agent 123 in Female CD-1 Mice[1].
pharmacokinetic indices dose i.v., p.o. (mg/kg) AUC0-24 (i.v., h·ng/mL) Vd (i.v., mL/kg) CL (i.v., mL/(kg·h)) t1/2 (i.v., h) AUC0-24 (p.o., h·ng/mL) Cmax (p.o., ng/mL) F (%)
compound 111 0.5, 10 (4.20 × 103) ± 308 322 ± 24 119 ± 9.2 1.88 ± 0.08 (4.33 × 104) ± 543 (3.10 × 103) ± 780 51.6 ± 5.2
Molecular Weight

441.25

Formula

C17H8F9N3O
CAS No.
SMILES

O=C1C=C(C(F)(F)F)NC2=C1C(NC3=NC=C(C(F)(F)F)C=C3)=CC(C(F)(F)F)=C2
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Antibacterial agent 123 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 1232615254-55-0Antibacterial agent123Antibacterial agent-123Bacterial5-aminoquinolin-4-onesAntibacterialbacteriaS. aureusmembrane-disruptingInhibitorinhibitorinhibit

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