Antibacterial agent 123

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Antibacterial agent 123 (compound 111) is a potent membrane-disrupting agent to combat antibiotic-resistant Gram-positive bacteria.

For research use only. We do not sell to patients.

Antibacterial agent 123 Chemical Structure

CAS No. : 2615254-55-0

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Purity & Documentation
References
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Description

Antibacterial agent 123 (compound 111) is a potent membrane-disrupting agent to combat antibiotic-resistant Gram-positive bacteria^[1].

In Vitro

Antibacterial agent 123 (compound 111) shows excellent activity (MIC<0.0625 μg/mL) toward S. aureus strains^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antibacterial agent 123 (compound 111) (p.o. (10 mg/kg) and i.v. (0.5 mg/kg); once) exhibits favorable pharmacokinetics profiles^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female CD-1 mice^[1]

Dosage:

0.5 mg/kg, 10 mg/kg

Administration:

p.o. (10 mg/kg) and i.v. (0.5 mg/kg); once (Pharmacokinetic Analysis)

Result:

Pharmacokinetic Parameters of Antibacterial agent 123 in Female CD-1 Mice^[1].

pharmacokinetic indices	dose i.v., p.o. (mg/kg)	AUC_0-24 (i.v., h·ng/mL)	Vd (i.v., mL/kg)	CL (i.v., mL/(kg·h))	t_1/2 (i.v., h)	AUC_0-24 (p.o., h·ng/mL)	C_max (p.o., ng/mL)	F (%)
compound 111	0.5, 10	(4.20 × 10³) ± 308	322 ± 24	119 ± 9.2	1.88 ± 0.08	(4.33 × 10⁴) ± 543	(3.10 × 10³) ± 780	51.6 ± 5.2

Molecular Weight

441.25

Formula

C₁₇H₈F₉N₃O

CAS No.

2615254-55-0

SMILES

O=C1C=C(C(F)(F)F)NC2=C1C(NC3=NC=C(C(F)(F)F)C=C3)=CC(C(F)(F)F)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Schultz JR, et al. Identification of 5-(Aryl/Heteroaryl)amino-4-quinolones as Potent Membrane-Disrupting Agents to Combat Antibiotic-Resistant Gram-Positive Bacteria. J Med Chem. 2022 Oct 11. [Content Brief]