2. Anti-infection
  3. Bacterial
  4. Antibacterial agent 127

Antibacterial agent 127 (Compound 23) is a potent antibacterial agent.

For research use only. We do not sell to patients.

Antibacterial agent 127 Chemical Structure

Antibacterial agent 127 Chemical Structure

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Antibacterial agent 127 Related Antibodies

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Description

Antibacterial agent 127 (Compound 23) is a potent antibacterial agent[1].

IC50 & Target

Bacterial[1]
In Vitro

Antibacterial agent 127 (Compound 23) (0-64 μg/mL; 20 h) shows antibacterial activity with MICs of 0.063, 0.063, 0.063, 0.25, 32 and 64 μg/mL against MSSA ATCC29213, MSSA ATCC25923, MRSAb, MRSEb, E.coli ATCC25922 and S.pullorum, respectively. And shows low cytotoxicity to RAW 264.7 cells (IC50＞100 μM)[1].
Antibacterial agent 127 shows good metabolic stability (t1/2 = 3.25 min in rat liver microsomes)[1].
Antibacterial agent 127 exhibits moderate inhibition effect on CYP3A4 (Midazolam) and CYP3A4 (Testosterone), with IC50 values of 2.64 and 1.94 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 127 Related Antibodies
In Vivo

Antibacterial agent 127 (Compound 23) (50 mg/kg; i.p.; single dose) inhibits MRSA effectively in a mouse thigh infection model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Kunming mice, neutropenic mouse thigh infection model[1]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection, single dose
Result: Reduced bacteria count with a value of 1.84 log10 CFU/mL in comparison with vehicle control group.
Molecular Weight

527.68

Formula

C28H37N3O5S
SMILES

C[C@]([C@@H](O)[C@@H]1C)(C[C@@H](OC(CSC(N2)=NC3=C(C=CN3)C2=O)=O)[C@@]4(C)[C@@]5([H])[C@]1(CCC5=O)CC[C@H]4C)C=C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antibacterial agent 127 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 127Antibacterial agent127Antibacterial agent-127BacterialMSSAMRSAbMRSEbE.coliS.pullorumInhibitorinhibitorinhibit

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