Antibacterial agent 154 

Antibacterial agent 154 (compound 7) is a derivative of Fluoroqinolones and is an orally effective antibacterial agent. Antibacterial agent 154 inhibits Gram-positive and Gram-negative bacteria. Antibacterial agent 154 demonstrated in vivo efficacy in a mouse model of staphylococcal sepsis^[1].

Antibacterial agent 154 (compound 7) inhibits Gram-positive bacteria M. luteus, B. subtilis, S. aureus, and S. epidermidis. The MICs are 4 μg/mL, 2 μg/mL, 2 μg/mL, and 2 μg/ mL; the MICs for inhibiting Gram-negative bacteria P. aerugenosa, E. coli, and S. typhimurium are 2 μg/mL and 2 μg/mL respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

518.97

C₂₅H₂₈ClFN₄O₅

2163048-45-9

OC1=C(C)N=CC(CN2CCN(C3=C(F)C=C4C(N(C5CC5)C=C(C(O)=O)C4=O)=C3)CC2)=C1CO.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Shtyrlin NV, et al. Synthesis and biological evaluation of fluoroquinolones containing a pyridoxine derivatives moiety. Eur J Med Chem. 2023 Sep 7;261:115798.. .  [Content Brief]