2. Anti-infection
  3. Bacterial
  4. Antibacterial agent 201

Antibacterial agent 201 (Compound 3) is an antibacterial agent through disruption of membrane integrity. Antibacterial agent 201 inhibits proliferation of Staphylococcus aureus strain RN4220, methacillin-resistane S. aureus, Pseudomonas aeruginosa strain PA01 and Escherichia coli strain ANS1 with MIC99s of 2.0, 1, 8.1 and 2.2 μg/mL, respectively.

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Antibacterial agent 201 Chemical Structure

Antibacterial agent 201 Chemical Structure

CAS No. : 1666171-29-4

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Description

Antibacterial agent 201 (Compound 3) is an antibacterial agent through disruption of membrane integrity. Antibacterial agent 201 inhibits proliferation of Staphylococcus aureus strain RN4220, methacillin-resistane S. aureus, Pseudomonas aeruginosa strain PA01 and Escherichia coli strain ANS1 with MIC99s of 2.0, 1, 8.1 and 2.2 μg/mL, respectively[1].

Cellular Effect
Cell Line Type Value Description References
HepG2 GI50
52.2 μM
Compound: 10
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth after 48 hrs by LDH assay
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth after 48 hrs by LDH assay
[PMID: 25684422]
In Vitro

Antibacterial agent 201 (0-100 μg/mL) exhibits cytotoxicity in cancer cells A549 and HEK293T, with CC50s of 64 and 32 μg/mL, respectively[1].
Antibacterial agent 201 (1-4 μg/mL) interacts synergisticly with Kanamycin (HY-16566)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: A549, HEK293T
Concentration: 0-100 μg/mL
Incubation Time: 48 h
Result: Exhibited cytotoxicity in A549 and HEK293T.
Molecular Weight

695.04

Formula

C41H54N6S2
CAS No.
SMILES

S=C(NCC(C1=CC=CC=C1)C2=CC=CC=C2)NCCCNCCCCCNCCCNC(NCC(C3=CC=CC=C3)C4=CC=CC=C4)=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antibacterial agent 201 Related Classifications

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Keywords:

Antibacterial agent 2011666171-29-4Antibacterial agent201Antibacterial agent-201BacterialStaphylococcus aureusPseudomonas aeruginosaEscherichia coliInhibitorinhibitorinhibit

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Antibacterial agent 201
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