Antibacterial agent 274 

Antibacterial agent 274 (Compound 18b) is a membrane-targeting antibacterial agent that demonstrates a MIC of 8 μg/mL against Acinetobacter baumannii ATCC 17978. By disrupting bacterial membrane integrity, it induces intracellular ROS accumulation and causes leakage of DNA and proteins, thereby exhibiting potent antibacterial activity. This compound is suitable for research applications targeting Gram-negative bacterial infections^[1].

1780.63

C₈₃H₁₁₀BrCl₂N₁₁O₂₃

C[N+]1(CCCCCCCCCCCC)CCN(C([C@]([H])(C2=CC(O)=CC(O)=C23)NC([C@@]4([H])NC([C@]([H])(NC([C@@H](C5=CC(OC(C=C6)=C(Cl)C=C6[C@H]7O)=C(O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O[C@@H]9O[C@@H](C)[C@@H](O)[C@](N)(C)C9)C(OC(C=C%10)=C(Cl)C=C%10[C@H]4O)=C5)NC([C@H](CC(N)=O)NC([C@@H]7NC([C@@H](CC(C)C)NC)=O)=O)=O)=O)C%11=CC3=C(O)C=C%11)=O)=O)=O)CC1.[Br-]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Li T, et al. Synthesis and antibacterial evaluations of novel vancomycin analogues targeting bacteria membrane to combat Gram-negative infections. Eur J Med Chem. 2025 May 5;289:117483.  [Content Brief]