Antibacterial agent 89 

Antibacterial agent 89 is a potent antibacterial agent. Antibacterial agent 89 shows anti-clostridial activity. Antibacterial agent 89 inhibits the release of cytotoxins and the β’CH-σ interaction. Antibacterial agent 89 disrupts the process of bacterial transcription^[1].

Antibacterial agent 89 (compound 8 e) shows antimicrobial activity for SPNE (Streptococcus pneumoniae (S. pneumoniae)) ATCC 49619, Streptococcus aureus (S. aureus) ATCC 25923, S. aureus ATCC 29213 with MIC of 2, 4, 4 µg/mL, respectively^[1].
Antibacterial agent 89 (48 h) shows anti-clostridial activity against clinically important Gram-positive pathogens with MIC of 0-8 µg/mL^[1].
Antibacterial agent 89 (48 h) inhibits the release of cytotoxins Toxin A (TcdA) and Toxin B (TcdB) in a dose-dependent manner in C. difficile ATCC 9689, ribotype 002, ribotype 027^[1].
Antibacterial agent 89 inhibits the β’CH-σ interaction with an IC₅₀ of 2.12 µM^[1].
Antibacterial agent 89 (1, 2, 4 µg/mL; B. subtilis) alters the localization of bacterial transcription complexes^[1].
Antibacterial agent 89 (0.5, 0.25 µg/mL) reduces the expression of DNA, RNA, protein levels in S. aureus ATCC 29213 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

516.27

C₂₁H₁₀Cl₂F₃NO₅S

2589639-87-0

O=C(C1=CC=C(C=C1C(C2=CC([N+]([O-])=O)=C(C=C2)SC3=CC(Cl)=C(C=C3)Cl)=O)C(F)(F)F)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ye J, et al. Benzyl and benzoyl benzoic acid inhibitors of bacterial RNA polymerase-sigma factor interaction. Eur J Med Chem. 2020 Dec 15;208:112671.  [Content Brief]