Antibiofilm agent-5 

Antibiofilm agent-5 (compound 6c) is a multitargeting antibacterial agent with potent antibiofilm activity. Antibiofilm agent-5 could induce metabolic dysfunction by deactivating lactate dehydrogenase and promote the accumulation of reactive oxygen species to decrease the reduced glutathione and ultimately cause oxidative damage in bacteria. Antibiofilm agent-5 can be used for the research of refractory biofilm-intensified bacterial infections^[1].

Antibiofilm agent-5 (compound 6c) shows better inhibitory activity towards Acinetobacter baumannii and Escherichia coli with MIC values both of 0.0066 mmol/L than norfloxacin (HY-B0132)^[1].
Antibiofilm agent-5 could insert into DNA to form the supramolecular complex of 6c-DNA and trigger cell death^[1].
Antibiofilm agent-5 shows a inconspicuous hemolysis effect on human red blood cell and low cytotoxicity on human normal hepatocytes (LO2) and lung epithelial cells (BEAS-2B), as well as no risk of crossing the blood-brain barrier^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

608.11

C₂₅H₃₄ClN₉O₅S

O=C(N1)NC(C2=C(Cl)N=C(CCCC)N2)C(C(OCC)=O)=C1CN3CCN(C(/C(C4=CSC(N)=N4)=N/OC)=O)CC3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Li W, et al. Novel aminothiazoximone-corbelled ethoxycarbonylpyrimidones with antibiofilm activity to conquer Gram-negative bacteria through potential multitargeting effects. Eur J Med Chem. 2024 Feb 13;268:116219.  [Content Brief]