ERCC1 Antibody (YA770)

ERCC1 Antibody (YA770) is a non-conjugated and Rabbit origined monoclonal antibody about 33 kDa, targeting to ERCC1. It can be used for WB, IF-Cell, IF-Tissue, IHC-P assays with tag free, in the background of Human.

ERCC1: The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]

Free

2067

Predicted band size: 33 kDa;Observed band size: 38 kDa

affinity purified

Cytoplasm, Nucleus.

Non-conjugated

Unmodified

Epigenetics and Nuclear Signaling

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal, Recombinant

Rabbit

Human

Mouse

P07992

WB: 1:1,000; IF-Cell: 1:50; IF-Tissue: 1:50; IHC-P: 1:50-1:100

WB, IHC-P, ICC/IF

HeLa cell lysate, A549 cell lysate, 293T cell lysate, SK-Br-3 cell lysate, Raji cell lysate, Hela, A549, HepG2, PANC-1, 293T, human kidney tissue.

Liquid

Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

Recombinant protein within Human ERCC1 aa 1-220 / 297.