GRP78 BiP Antibody (YA746)

GRP78 BiP Antibody (YA746) is a non-conjugated and Mouse origined monoclonal antibody about 72 kDa, targeting to GRP78 BiP (4F11). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

GRP78 BiP (4F11): The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. [provided by RefSeq, Jul 2020]

Free

3309

Predicted band size: 72 kDa

affinity purified

Non-conjugated

Unmodified

Tags & Cell Markers

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat

P11021

WB: 1:500-1:1,000 ;IF: 1:50-1:200 ;IP: 1:20

WB, ICC/IF, IP

Liquid

Supplied in 1*PBS (pH 7.3), 50% glycerol and 0.5% BSA. Preservative: 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2b

Endogenous

Synthetic peptide corresponding to Human BiP/GRP78.The exact sequence is proprietary to MCE.