HLA DQA1 Antibody (YA2433)

HLA DQA1 Antibody (YA2433) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2433), targeting HLA DQA1, with a predicted molecular weight of 28 kDa (observed band size: 28 kDa). HLA DQA1 Antibody (YA2433) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.

HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.

3117

Predicted band size: 28 kDa; Observed band size: 28 kDa

Affinity Chromatography

Non-conjugated

Unmodified

Immunology

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human, Mouse, Rat

P01909

WB: 1/500-1/1000;IHC: 1/50-1/100;IP: 1/50

WB, IHC-P, IP

Liquid

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human HLA-DQA1