HSD17B1 Antibody (YA3048)

HSD17B1 Antibody (YA3048) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3048), targeting HSD17B1, with a predicted molecular weight of 35 kDa (observed band size: 35 kDa). HSD17B1 Antibody (YA3048) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human background.

The related gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. The related gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in The related gene have been linked to breast and prostate cancer. A pseudorelated gene of The related gene has been identified. Alternative splicing results in multiple transcript variants.

3292

Predicted band size: 35 kDa; Observed band size: 35 kDa

Affinity Purified

Non-conjugated

Unmodified

Signal Transduction

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

P14061

WB: 1/500-1/1000;IHC: 1/50-1/100;IF: 1/50-1/200;IP: 1/20

WB, IHC-F, IHC-P, ICC/IF, IP

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthetic peptide of human HSD17B1