Kininogen 1 Antibody (YA2140)

Kininogen 1 Antibody (YA2140) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2140), targeting Kininogen 1, with a predicted molecular weight of 72 kDa (observed band size: 56/130 kDa). Kininogen 1 Antibody (YA2140) can be used for WB, IHC-P, IP experiment in human background.

The related gene uses alternative splicing to related generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reduces or depletes angiotensin converting enzyme 2 (ACE2), which results in an increase in levels of des-Arg(9)-bradykinin, a bioactive metabolite of bradykinin that is associated with lung injury and inflammation. Three transcript variants encoding different isoforms have been found for The related gene.

3827

Predicted band size: 72 kDa; Observed band size: 56,130 kDa

Affinity Chromatography

Non-conjugated

Unmodified

Cell Biology

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

P01042

WB: 1/500-1/1000;IHC: 1/50-1/100;IP: 1/50

WB, IHC-P, IP

Liquid

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human Kininogen 1