MBD2 Antibody (YA2279)

MBD2 Antibody (YA2279) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2279), targeting MBD2, with a predicted molecular weight of 43 kDa (observed band size: 43/32/29 kDa). MBD2 Antibody (YA2279) can be used for WB, IHC-P, ICC/IF experiment in human background.

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated related gene promoters. The protein encoded by The related gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the The protein functions as a demethylase to activate transcription, as DNA methylation causes related gene silencing. Two transcript variants encoding different isoforms have been found for The related gene.

8932

Predicted band size: 43 kDa; Observed band size: 43,32,29 kDa

Affinity Chromatography

Non-conjugated

Unmodified

Epigenetics and Nuclear Signaling

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

Q9UBB5

WB: 1/500-1/1000;IHC: 1/50-1/100;IF: 1/50-1/200

WB, IHC-P, ICC/IF

Liquid

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human MBD2