MCM6 Antibody (YA1146)

MCM6 Antibody (YA1146) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1146), targeting MCM6. MCM6 Antibody (YA1146) can be used for IHC-P experiment in human background.

The protein encoded by The related gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of The protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of The related gene are associated with differential transcriptional activation of the promoter of the neighboring lactase related gene and, thereby, influence lactose intolerance in early adulthood.

4175

Affinity Purified

Non-conjugated

Unmodified

Epigenetics and Nuclear Signaling

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

Q14566

IHC: 1/100-1/200

IHC-P

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.189.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

Recombinant protein of human MCM6