MICA+MICB Antibody (YA3560)

MICA+MICB Antibody (YA3560) is a rabbit-derived non-conjugated IgG antibody, targeting MICA. MICA+MICB Antibody (YA3560) can be used for WB, FC, IP experiment in human background.

The related gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in The related gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of The related gene results in multiple transcript variants.

100507436

Predicted band size: 43 kDa； Observed band size: 60 kDa

affinity purified

Cell membrane, Cytoplasm; Cell membrane.

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal, Recombinant

Rabbit

Human

SwissProt: Q29980 Human； SwissProt: Q29983 Human

WB: 1:2,000; FC: 1:1,000; IP: 1-2μg/sample

WB, IP, FC

K-562 cell lysate, HL-60 cell lysate, Jurkat cell lysate, HeLa cell lysate, HUVEC cell lysate, HeLa.

Liquid

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Recombinant protein within human MICB aa 1-309.