MUC16 Antibody (YA890)

MUC16 Antibody (YA890) is an unconjugated, approximately 1519 kDa, anti-MUC16 (YA890) monoclonal antibody. MUC16 Antibody (YA890) can be used for: WB, IF-Cell, IF-Tissue, IHC-P, FC expriments in human background without labeling.

The related gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. The protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of The related gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes.

94025

Predicted band size: 1519 kDa

Affinity purified

Cell membrane, extracellular space.

Non-conjugated

Unmodified

Tags & Cell Markers

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

Q8WXI7 Human

WB: 1:1,000;IF-Cell: 1:100-1:500;IF-Tissue: 1:100-1:500

WB, ICC/IF, IHC-P, FC

Liquid

Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

Recombinant protein within Human MUC16 aa 12331-12339 / 14,507.