Nicastrin Antibody (YA1397)

Nicastrin Antibody (YA1397) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1397), targeting Nicastrin, with a predicted molecular weight of 78 kDa (observed band size: 110-120 kDa). Nicastrin Antibody (YA1397) can be used for WB, IP experiment in human, mouse, rat background.

The related gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in The related gene are associated with familial acne inversa. A pseudorelated gene of The related gene is present on chromosome 21. Alternatively spliced transcript variants of The related gene have been described, but the full-length nature of some of these variants has not been determined.

23385

Predicted band size: 78 kDa; Observed band size: 110-120 kDa

Affinity Purified

Non-conjugated

Unmodified

Neuroscience

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human, Mouse, Rat

Q92542

WB: 1/500-1/1000;IP: 1/20

WB, IP

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthetic peptide of human Nicastrin